In press

Chromosomes in the Genomic Age. Preserving Cytogenomic Competence of Diagnostic Genome Laboratories. Ron Hochstenbach, Thomas Liehr, Ros Hastings (2020) In press.

Opportunistic genomic screening. Recommendations of the European Society of Human Genetics. EJHG In press.  Guido de Wert, Wybo Dondorp, Angus Clarke,  Zandra Deans, Carla van El, Florence Fellmann , Ros Hastings, Sabine Hentze, Heidi Howard, Alvaro Mendes, Chris Patch, Emmanuelle Rial-Sebbag, Vigdis Stefansdottir, Martina Cornel, Francesca Forzano. 

The International Collaboration for Cancer Classification and Research (IC3R).  Ian A. Cree, Iciar Indave, Jiri Zavadil, James McKay, Magali Olivier, Zisis Kozlakidis, Alexander J. Lazar, Chris Hyde, Stefan Holdenreider, Ros Hastings, Nasir Rajpoot, Arnaud de la Fouchardiere, Brian Rous, Jean Claude Zenklusen, Nicola Normanno, Richard L. Schilsky. 


European recommendations and quality assurance for cytogenomic analysis of haematological neoplasms: response to the comments from the Francophone Group of Hematological Cytogenetics (GFCH). Rack KA, van den Berg E, Haferlach C, Beverloo HB, Costa D, Espinet B, Foot N, Jeffries S, Martin K, O'Connor S, Schoumans J, Talley P, Telford N, Stioui S, Zemanova Z, Hastings RJ Leukemia. 2020 Feb 7. doi: 10.1038/s41375-020-0736-x. [Epub ahead of print]

One byte at a time: evidencing the quality of clinical service next generation sequencing for germline and somatic variants.  Maria Weronika Gutowska-Ding, Zandra C. Deans, Christophe Roos, Jukka Matilainen, Farrah Khawaja, Kim Brügger, Jo Wook Ahn, Christopher Boustred, Simon J. Patton.  2019.  European Journal of Human Genetics

Standardising copy number variant (CNV) and single nucleotide variants (SNV) classification through external quality assessment. R Hastings, K Rack, F Khawaja, R Treacy, ZC Deans.  2019 Asia Conference on Human Genetics, Manila, Phillipines. [POSTER]

Ensuring competency of clinicians and scientists classifying the pathogenicity of single nucleotide variants.  ZC Deans, F Khawaja, R Treacy.  2019 Asia Conference on Human Genetics, Manila, Phillipines. [POSTER]

Guidance for reporting the interpretation of cytogenomic test results in haematological neoplasms.  Katrina Rack, Eva van den Berg, Claudia Haferlach, Berna Beverloo, Blanca Espinet, Nicola Foot, Kate Martin, Sheila O'Connor, Jacqueline Schoumans, Polly Talley, Sabine Stioui, Zuzana Zemanova, Isabelle Luquet, Ros Hastings. Atlas Genet Cytogenet Oncol Haematol. 2019.

ACGS Best Practice Guidelines for Variant Classification 2019Sian Ellard, Emma L Baple, Ian Berry, Natalie Forrester, Clare Turnbull, Martina Owens, Diana M Eccles, Stephen Abbs, Richard Scott, Zandra C Deans, Tracy Lester, Jo Campbell, William G Newman and Dominic J McMullan.

IQN path ASBL report from the first European cfDNA consensus meeting: expert opinion on the minimal requirements for clinical ctDNA testing.  Deans ZC, Butler R, Cheetham M, Dequeker EMC, Fairley JA, Fenizia F, Hall JA, Keppens C, Normanno N, Schuuring E, Patton SJ.  Virchows Arch (2019).

Findings from the global external quality assessment of lung cancer liquid biopsy testing.  J Fairley, M Cheetham, M Dennis, E Dequeker, C Keppens, F Fenizia, N Normanno, S Patton, E Rouleau, K van Casteren, ZC Deans.  2019 Association for Molecular Pathology (AMP) Annual Meeting, Baltimore, USA [POSTER]

Ensuring high standards for the delivery of NIPT world-wide: Development of an international external quality assessment scheme. Deans ZC, Allen S, Jenkins L, Khawaja F, Gutowska-Ding W, Patton SJ, Chitty LS, Hastings RJ.  Prenatal Diagnosis. 2019. Feb 14. doi: 10.1002/pd.5438. 

European recommendations and quality assurance for cytogenomic analysis of haematological neoplasms.  KA Rack, E van den Berg, C Haferlach, HB Beverloo, D Costa, B Espinet, N Foot, S Jeffries, K Martin, S O’Connor, J Schoumans, P Talley, N Telford, S Stioui, Z Zemanova & RJ Hastings. Leukaemia 2019.

External Quality Assessment (EQA) for genomics and clinical genetics - ensuring the quality of the entire genetics service.  R Hastings, K Rack, J Fairley, F Morgan, M Sales, ZC Deans. 2019 European Cytogeneticist Association (ECA) Conference, Salzburg, Austria [POSTER]

Individual assessment for single nucleotide variant classification using the Genomics Training, Assessment and Competency Tool (G-TACT).  R Treacy, F Khawaja, ZC Deans. 2019 European Society of Human Genetics (ESHG) conference, Uppsala, Sweden [POSTER]

Newborn screening EQA for cystic fibrosis (CF) and Medium-chain acyl-CoA dehydrogenase deficiency (MCADD): ten year review (2008-2018).  F Moon, R Treacy, ZC Deans.  2019 European Society of Human Genetics (ESHG) conference, Uppsala, Sweden [POSTER]

Oncologists Review of ctDNA EGFR mutation testing reports.  G Holland, N Iley, R Butler, F Blackhall, D Talbot, A Greystoke, ZC Deans. 2019 Association for Molecular Pathology (AMP) Global Congress, Hong Kong. [POSTER]

Best Practice for integrating cell-free DNA based NIPT into clinical practice. Zandra C. Deans, Nicola Wolstenholme, Ros J Hastings. Non-invasive Prenatal Testing (NIPT), Chapter 11:191-205. Academic Press. 2018 

Validation of the Oncomine™ focus panel for next-generation sequencing of clinical tumour samples.  Williams HL, Walsh K, Diamond A, Oniscu A, Deans ZC. Virchows Arch. 2018 Oct;473(4):489-503. doi: 10.1007/s00428-018-2411-4. 

Results of the UK NEQAS for Molecular Genetics Reference Sample analysis. Richman SD, Fairley J, Hall JA, Nataraj N, Bhide M, Lau A, Norman KL, Deans ZC. J Clin Pathol. 2018 Jul 20. pii: jclinpath-2018-205277. 

International pilot external quality assessment scheme for analysis and reporting of circulating tumour DNA. Keppens C, Dequeker EMC, Patton SJ, Normanno N, Fenizia F, Butler R, Cheetham M, Fairley JA, Williams H, Hall JA, Schuuring E, Deans ZC. BMC Cancer. 2018 Aug 9;18(1):804.

European Cytogeneticist Association (ECA) newsletter (41) Jan 2018

Delivering an accredited non-invasive prenatal diagnosis service for monogenic disorders and recommendations for best practice. Jenkins LA, Deans ZC, Lewis C, Allen S. Prenat Diagn. 2018,38:44-51

European Guidelines for Constitutional Cytogenomic Analysis.  (2018) Silva M, Leeuw N, Mann K, Schuring-Blom H, Morgan M, Giardino D, Rack K,  Hastings. R. Eur J Hum Genet.

Recommended practice for laboratory reporting of non-invasive prenatal testing of trisomies 13, 18 and 21: a consensus opinionDeans ZC, Allen S, Jenkins L, Khawaja F, Hastings RJ, Mann K, Patton SJ, Sistermans EA, Chitty LS. Prenat Diagn. 2017 Jul;37(7):699-704. doi: 10.1002/pd.5068. Epub 2017 Jun 8.

How close are we to standardised extended RAS gene mutation testing? The UK NEQAS evaluation. Richman SD et al. J Clin Pathol. 2017 Jan;70(1):58-62.

Integration of next-generation sequencing in clinical diagnostic molecular pathology laboratories for analysis of solid tumours; an expert opinion on behalf of IQN Path ASBL. Deans ZC et al. Virchows Arch. 2017 Jan;470(1):5-20.             

The ins and outs of molecular pathology reporting. Tack V, Dufraing K, Deans ZC, van Krieken HJ, Dequeker EM. Virchows Arch. 2017 Mar 26.

Developing effective ctDNA testing services for lung cancer PHG Foundation Report (2017). Laura Blackburn, Leila Luheshi, Sandi Deans, Mark Kroese and Hilary Burton.

Review of the implementation of plasma ctDNA testing on behalf of IQN Path ASBL: A perspective from an EQA providers survey. Zandra C Deans, Hannah Williams, Elisabeth MC Dequeker, Cleo Keppens, Nicola Normanno, Ed Shuuring, Simon Patton, Melanie Cheetham, Rachel Butler, Jacqueline Hall. Virchows Archiv. 2017 Aug 25.

RAS screening in colorectal cancer: A comprehensive analysis of the results from the UK NEQAS Colorectal Cancer External Quality Assurance schemes (2009-2016). Susan D. Richman, Jennifer Fairley, Rachel Butler, Zandra C. Deans. Virchows Archiv. 2017 Jun 26.

Delivering an accredited non-invasive prenatal diagnosis service for monogenic disorders and recommendations for best practice. Jenkins LA, Deans ZC, Lewis C, Allen S.Prenat Diagn. 2017 Dec 20. doi: 10.1002/pd.5197. [Epub ahead of print]

Cytogenetic nomenclature and reporting. Stevens-Kroef M, Simons A, Rack K, Hastings RJ. Methods Mol Biol. 2017;1541:303-309. Review

Fading competence of cytogenetic diagnostic laboratories: the alarm bell has started to ring. Hochstenbach R, Slunga-Tallberg A, Devlin C, Floridia G, de Alba MR, Bhola S, Rack K, Hastings R. Eur J Hum Genet. 2017 Feb;25(3):273-274.

Guidelines for genomic array analysis in acquired haematological neoplastic disorders.  Schoumans J, Suela J, Hastings R, Muehlematter D, Rack K, van den Berg E, Berna Beverloo H, Stevens-Kroef M. Genes Chromosomes Cancer. 2016 May;55(5):480-91. doi: 10.1002/gcc.22350. Epub 2016 Feb 23.

HGVS Nomenclature in Practice: An Example from the United Kingdom National External Quality Assessment Scheme. Deans ZC, Fairley JA, den Dunnen JT, Clark C. Hum Mutat. Jun;37(6):576-8. doi: 10.1002/humu.22978. Epub 2016 Mar 18

What's in a Name? A Coordinated Approach toward the Correct Use of a Uniform Nomenclature to Improve Patient Reports and Databases. Tack V, Deans ZC, Wolstenholme N, Patton S, Dequeker EM. Hum Mutat. 2016 Jun;37(6):570-5. doi: 10.1002/humu.22975. Epub 2016 Mar 14 

Raising the standards of routine genetic testing. Zandra Deans Hospital Healthcare Europe 2015. 

Guidance for laboratories performing molecular pathology for cancer patients. Cree IA, Deans Z, Ligtenberg MJ, Normanno N, Edsjö A, Rouleau E, Solé F, Thunnissen E, Timens W, Schuuring E, Dequeker E, Murray S, Dietel M, Groenen P, Van Krieken JH; European Society of Pathology Task Force on Quality Assurance in Molecular Pathology and the Royal College of Pathologists. J Clin Pathol. 2014 Nov;67(11):923-31

Next generation diagnostic molecular pathology: critical appraisal of quality assurance in Europe. Dubbink HJ, Deans ZC, Tops BB, van Kemenade FJ, Koljenović S, van Krieken HJ, Blokx WA, Dinjens WN, Groenen PJ. Mol Oncol. 2014 Jun;8(4):830-9. doi: 10.1016/j.molonc.2014.03.004. Epub 2014 Mar 18. Epub 2014 Jul 10.

External quality assessment of BRAF molecular analysis in melanoma. Deans ZC, Wallace A, O'Sullivan B, Purvis A, Camus S, Fairley JA, Gonzalez D. J Clin Pathol. 2014 Feb;67(2):120-4. doi: 10.1136/jclinpath-2013-201848. Epub 2013 Oct 4.

European consensus conference for external quality assessment in molecular pathology. van Krieken JH, Siebers AG,Normanno N, Blackhall F, Boone E, Hartziekenhuis H, Botti G, Carneiro F, Celik I, Ciardiello F, Cree IA, Deans ZC,Dequeker E, Edsjö A, Groenen PJ, Kamarainen O, Kreipe HH, van Krieken JH, Ligtenberg MJ, Marchetti A, Murray S,Normanno N, Opdam FJ, Patterson SD, Patton S, Pinto C, Rouleau E, Schuuring E, Siebers AG, Sterck S, Taron M,Tejpar S, Timens W, Thunnissen E, van de Ven PM. Ann Oncol. 2013 Aug;24(8):1958-63. doi: 10.1093/annonc/mdt153. Epub 2013 Apr 23.

Improvement in the quality of molecular analysis of EGFR in non-small cell lung cancer detected by three rounds of external quality assessment. Deans ZC, Bilbe N, O'Sullivan B, Lazarou LP, de Castro DG, Parry S, Dodson A, Taniere P, Clark C, Butler R. J Clin Pathol. 2013 Apr;66(4):319-25. doi: 10.1136/jclinpath-2012-201227. Epub 2013 Feb 1.

The UK NEQAS for Molecular Genetics scheme for gastrointestinal stromal tumour: findings and recommendations following four rounds of circulation. Wong NA, Deans ZC, Ramsden SC. J Clin Pathol. 2012 Sep;65(9):786-90. doi: 10.1136/jclinpath-2012-200851. Epub 2012 Jun 9.

Guideline on the requirements of external quality assessment programs in molecular pathology. van Krieken JH, Normanno N, Blackhall F, Boone E, Botti G, Carneiro F, Celik I, Ciardiello F, Cree IA, Deans ZC, Edsjö A, Groenen PJ, Kamarainen O, Kreipe HH, Ligtenberg MJ, Marchetti A, Murray S, Opdam FJ, Patterson SD, Patton S, Pinto C, Rouleau E, Schuuring E, Sterck S, Taron M, Tejpar S, Timens W, Thunnissen E, van de Ven PM, Siebers AG, Dequeker E. Virchows Arch. 2013 Jan;462(1):27-37. Epub 2012 Dec 19.

The experience of three years of external quality assessment of preimplantation genetic diagnosis for cystic fibrosis. Deans Z, Fiorentino F, Biricik A, Traeger-Synodinos J, Moutou C, De Rycke M, Renwick P, Sengupta S, Goossens V, Harton G. Eur J Hum Genet. 2013 Aug;21(8):800-6. doi: 10.1038/ejhg.2012.244. Epub 2012 Nov 14.

Molecular genetics external quality assessment pilot scheme for KRAS analysis in metastatic colorectal cancer. Deans ZC, Tull J, Beighton G, Abbs S, Robinson DO, Butler R. Genet Test Mol Biomarkers. 2011 Nov;15(11):777-83. doi: 10.1089/gtmb.2010.0239. Epub 2011 Aug 18.

Monitoring standards for molecular genetics testing in the United Kingdom, the Netherlands and Ireland. Ramsden SC,Deans Z, Robinson DO, Mountford R, Sistermans EA, Grody WW, McQuaid S, Patton SJ, Stenhouse SA. Genet Test. 2006 Fall;10(3):147-56.



Last updated: Tuesday, 14 April 2020
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